Restylane® Refyne Lidocaine (1 x 1ml)

General Information

Restylane® Refyne Lidocaine is a hyaluronic acid-based injectable dermal filler developed by Galderma. It contains 20 mg/mL of cross-linked hyaluronic acid and 0.3% lidocaine to help reduce discomfort during injection. Its flexible gel formulation is designed to soften moderate-to-severe facial wrinkles and folds while supporting natural-looking facial expressions.

The product is supplied in a prefilled 1 mL syringe and is intended for administration by appropriately trained healthcare professionals in accordance with the manufacturer’s instructions and local regulations.

Indications for Restylane® Refyne Lidocaine

Restylane® Refyne is designed for facial wrinkle correction, particularly in areas where natural facial movement is important.

Potential treatment objectives include:

• Nasolabial fold correction: Reduces the appearance of folds extending from the sides of the nose toward the corners of the mouth.
• Facial wrinkle smoothing: Improves the appearance of moderate facial wrinkles and folds.
• Natural-looking results: Supports facial contour refinement while preserving natural expressions.
• Facial rejuvenation: Helps restore a smoother appearance in appropriately selected treatment areas.

In the United States, Restylane® Refyne is indicated for correction of moderate-to-severe facial wrinkles and folds, such as nasolabial folds, in adults over 21. Approved indications may vary by country.

Contraindications and Precautions

Before treatment, a qualified practitioner should review the patient’s medical history, allergies, medications, and previous aesthetic procedures.

Important contraindications and precautions include:

• Severe allergies: History of anaphylaxis or multiple severe allergies.
• Ingredient sensitivities: Allergy to lidocaine, amide-type local anesthetics, or relevant bacterial proteins.
• Porphyria: Listed as a contraindication in the manufacturer’s instructions.
• Active skin infections: Treatment should be postponed in affected areas until the condition resolves.
• Bleeding risks: Anticoagulants and bleeding disorders may increase bruising or bleeding.
• Pregnancy and breastfeeding: Safety has not been established; follow the applicable product instructions.

Potential Side Effects

Common reactions may include:

• Redness, swelling, and bruising
• Tenderness or injection-site pain
• Itching and temporary discoloration
• Firmness, lumps, or bumps

Rare but serious complications include vascular occlusion, tissue necrosis, visual impairment, blindness, and stroke. Severe pain, unusual skin discoloration, sudden visual changes, or neurological symptoms after injection require immediate emergency medical attention.

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